Next generation electrophysiology with Neuropixels probes allow us to record the activity of hundreds of neurons across many brain regions simultaneously.
Optogenetics is a crucial technology for identifying and recording the activity of discrete cell types in the brain during behavior and for perturbing neural circuits to probe their function.
Large-scale neuroanatomy leveraging new viral, genetic, computational, and imaging tools provides a substrate for new hypotheses of brain function.
In vivo imaging
Ultra-sensitive fluorescent sensors of both spiking and neurotransmitter/neuromodulator release allow us to monitor the activity of genetically identified neural populations during behavior.
We use single-cell RNA sequencing to identify and ultimately target genetically specified neural populations that have distinct roles in motor control.
We study neural circuits while mice are engaged in goal-directed behavior and use computer vision to measure their movements quantitatively. Studying tongue and jaw movements gives us a rich and experimentally tractable model for motor control.